Health


Smallholder pig production in northern Viet Nam

Farmer Ma Thi Puong feeds her pigs on her farm near the northern town of Mieu Vac, Vietnam (photo credit: ILRI/Stevie Mann).

One Health is an interdisciplinary approach to combating emerging infectious diseases by addressing the complex interactions of human health, animal health and the environment.

The One Health approach encourages the collaborative efforts of multiple disciplines working locally, nationally, regionally and globally to attain optimal health for people, animals and the environment.

Seventy-five per cent of all new, emerging or re-emerging diseases affecting humans at the beginning of the 21st century originated in animals.These zoonotic diseases present serious public health, economic and development challenges.

The subject of One Health took centre stage during the August 2013 International Symposium of Health Sciences (i-SIHAT 2013) held in Kuala Lumpur, Malaysia.

In a keynote presentation at the start of the symposium, Hung-Nguyen Viet – a researcher at the Center for Public Health and Ecosystem Research (CENPHER) at the Hanoi School of Public Health who is on a joint appointment at the International Livestock Research Institute (ILRI) – discussed a regional One Health initiative in Southeast Asia and how this integrated approach is working to develop the capacity of universities to respond to the threat of emerging infectious diseases.

View the presentation, One Health – an interdisciplinary approach in combating emerging diseases

Maize contaminated with aflatoxin

Maize contaminated with aflatoxin (photo credit: IITA).

On 22 August 2013, the Biosciences eastern and central Africa hub at the International Livestock Research Institute (ILRI) and ILRI’s Food Safety and Zoonoses program hosted a half-day seminar on the current status on aflatoxin research and management at ILRI.

The open forum was an opportunity for different working groups to engage in discussions on the ongoing and planned research projects. The seminar brought together some 30 participants and a total of 13 presentations were given on aflatoxin assessment, diagnostics, analysis and mitigation.

Aflatoxins are highly toxic metabolites produced by the mould Aspergillus flavus and known to cause suppression of the immune system, liver disease and death in both humans and animals.

Aspergillus can grow in a wide range of foods and feed and thrive under favourable growth conditions of high temperature and moisture content. Aflatoxins from contaminated animal feed can end up in milk.

Three research studies that are part of the project Measuring and mitigating the risk of mycotoxins in maize and dairy products for poor consumers in Kenya (MyDairy project) were featured during the seminar.

The goal of the MyDairy project – the fifth of seven work packages of the FoodAfrica program – is to reduce the risk of mycotoxin contamination of staple crops in Kenya.

ILRI graduate fellow Anima Sirma presented an overview of her planned PhD research on risk assessment of aflatoxins in the Kenyan dairy value chain. The objectives of the study are to characterize the key risks of aflatoxins, identify the best control options and provide risk managers with information for decision-making.

Daniel Senerwa, another ILRI graduate fellow working towards a PhD, presented his proposed research that seeks to quantify the economic costs of aflatoxins in the Kenyan dairy value chain and examine the cost effectiveness of mitigation strategies.

Sirma and Senerwa are veterinary scientists and are undertaking their PhD studies at the University of Nairobi’s Faculty of Veterinary Sciences.

Sara Ahlberg, a dairy technologist from Finland and ILRI associate research officer, presented an overview of her work on a novel biological method to mitigate aflatoxin-induced risks in food and feed with dairy-derived proteins and peptides and lactic acid bacteria that have the ability to bind aflatoxins or inhibit the growth of mycotoxin-producing moulds.

Download the seminar report

Sale of raw milk at Port-Bouët market in Abidjan, Côte d’Ivoire

Sale of raw milk at Port-Bouët market in Abidjan, Côte d’Ivoire (photo credit: ILRI/Sylvie Mireille Kouamé-Sina).

Every day, some 652 consumers of raw milk in Abidjan, Côte d’Ivoire are exposed to the risk of gastro-intestinal infection caused by harmful milk-borne bacteria, a study has shown. The study was done under the collaborative Safe Food, Fair Food project which is led by International Livestock Research Institute (ILRI).

As is the case in most countries in sub-Saharan Africa, milk in the informal or traditional market in Côte d’Ivoire is often sold raw. Many consumers routinely boil milk before drinking it, thus eliminating the health risk presented by milk-borne pathogens. However, some choose to consume the milk raw without any form of heat treatment. Unhygienic handling and storage of milk can also compromise the quality of raw milk sold to consumers.

Sylvie Mireille Kouamé-Sina, an Ivorian researcher at the Centre Suisse de Recherches Scientifiques en Côte d’Ivoire (CSRS), led the study on bacterial risk assessment of informally marketed milk in Abidjan.

Just over half (51.6%) of sampled milk consumers in Abidjan reportedly drank their milk raw. The main disease-causing bacteria isolated from the marketed raw milk were E. coli, Enterococcus sp. and Staphylococcus aureus. These species were found in about 58% of samples of informally marketed milk.

A risk model revealed that consumers of raw milk in Abidjan have a 30% chance of drinking milk that is not microbiologically safe. For this reason, boiling of informally marketed milk is recommended as a risk-mitigation strategy against milk-borne pathogenic bacteria.

Kouamé-Sina presented these findings during a poster session at the 5th Congress of European Microbiologists (FEMS 2013) which was held on 21-25 July 2013 in Leipzig, Germany. The international conference brought together 2270 participants from 70 countries across all continents. Africa was represented by 27 participants from Côte d’Ivoire (1), Egypt (2), Nigeria (11), South Africa (12) and Tunisia (1).

Various topics on the latest advances in microbiology and biotechnology were discussed, including microbial food safety, trends in pathogen monitoring, viral ecology and evolution, new perspectives in bioenergy, and microbial interactions and climate change.

“The conference was a very interesting forum for thousands of international microbiologists from Europe and around the world to assess the current status of techniques used in microbiology,” said Kouamé-Sina.

“It was especially useful for young scientists as it allowed for interaction with leading researchers and exchange of knowledge and information on the latest advances in microbiology,” she added.

View the poster, Bacterial risk assessment of milk produced locally in Abidjan, Côte d’Ivoire

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Read more about ILRI’s research on food safety in informal markets.

Cover of special issue of Vietnam Journal of Preventive Medicine on risk assessment

The Vietnamese Journal of Preventive Medicine has published a special edition on risk assessment for health research in Vietnam. The June 2013 special edition is a compilation of over 10 original research papers on the application of risk analysis to the management of animal, human and environmental health in Vietnam. The subject of training and capacity development in health risk assessment in Vietnam is also featured.

Risk analysis is a scientific, risk-based approach to assessing the health effects and economic impacts of various hazards (for example, disease-causing microorganisms in food or chemical pollutants in water) in order to develop appropriate interventions to mitigate the health risks posed by the hazards, thus ensuring that people, animals and the environment are safe.

Risk analysis comprises three components: risk assessment, risk management and risk communication. In the developed world, risk assessment is widely applied and used as a tool for risk management, thanks to the availability and accessibility of large databases of diseases.

However, many developing countries – including Vietnam – do not have the research data and risk analysis expertise needed to be able to adequately inform policymaking on risk-based approaches to health management.

The research papers featured in the special issue provide insights into the current status of research on risk analysis in Vietnam, specifically, risk assessment of the health impacts of Salmonella, E. coli and Listeria monocytogenes in the pork value chain in Hanoi, arsenic contamination in drinking water in Hanam Province, dioxin contamination in food in Da Nang and pesticide residues in farms in Thai Binh.

The work is a result of the collaborative efforts of the Vietnamese Journal of Preventive Medicine and the Center for Public Health and Ecosystem Research (CENPHER) at the Hanoi School of Public Health (HSPH).

Among the co-authors of the research papers are Delia Grace and Lucy Lapar, scientists at the International Livestock Research Institute (ILRI), and Hung Nguyen-Viet who leads research at CENPHER-HSPH and is a joint appointee of the Swiss Tropical and Public Health Institute and ILRI.

The papers are in Vietnamese with abstracts available in English. Listed below are the titles of the papers.

  • Risk assessment and health research in Vietnam (editorial)
  • Risk assessment of Salmonella in pork in Hanoi, Vietnam
  • Food-borne hazards in a transforming pork value chain in Hanoi: Basis for future risk assessments
  • Health risk due to exposure to chlorpyrifos for farmers in Thai Binh: Probabilistic risk assessment
  • Risk assessment of arsenic contamination in tube-well drinking water in Hanam Province
  • Environmental health risk assessment of dioxin in foods in Da Nang dioxin hot spot
  • Prevalence of Salmonella contamination in pig and pork at farms and slaughterhouses in the northern provinces of Vietnam
  • Air pollution as a health issue in Hanoi, Vietnam: An opportunity for intensified research to inform public policy
  • Environmental health risk communication: Concept, principles and challenges
  • Training and research programs in health risk assessment in Vietnam
  • Task force of risk assessment for food safety in Vietnam: Linking science to policy to increase food safety and livelihood generation of the poor farmer
  • Research projects on health risk assessment implemented by the Hanoi School of Public Health

The special edition also includes news on risk assessment training in Vietnam and reviews of two books on risk assessment.

For more information on this special edition, please contact Hung Nguyen-Viet (hung.nguyen @ unibas.ch).

Beef and pork sellers in Maputo's traditional market

Traders in beef and pork meat at the Xipamanine traditional market in Maputo, Mozambique (photo credit: ILRI/Stevie Mann).

In many countries of sub-Saharan Africa, informal markets play an important role in supplying most of the meat, milk, eggs and fish that poor people depend on for their nourishment.

Informal markets are those where traditional processing and products predominate and where traders are often unlicensed and do not pay tax.

Examples include street food markets, milk hawking systems, wet markets for pork, backyard poultry systems and artisanal production of cheese and other fermented milk products.

Despite the important role of Africa’s informal food markets in providing nutrition, employment and income to millions of people, these markets are often not subject to effective health and safety regulation.

Several approaches to food safety in informal markets have focused on food-borne hazards, with a tendency to adopt stringent international food quality standards with little regard for local contexts.

On the other hand, risk-based approaches to food safety do not just consider the presence or absence of food-borne hazards, but go further to assess whether there are certain practices that can minimize the health risks presented by the hazards.

Take, for example, the case of raw milk which is often sold informally in many parts of sub-Saharan Africa.

It is well known that raw milk is a good medium for microbial growth and is prone to microbial spoilage if not cooled immediately after milking.

Pathogenic species like E. coli often occur naturally in raw milk. However, most consumers in Africa routinely boil milk before they drink it, a simple practice that effectively kills any milk-borne pathogens, thus rendering the milk safe to drink.

A hazard-based approach to food safety that focuses solely on the hazard (E. coli in raw milk) would quickly condemn the milk as ‘unsafe for human consumption’.

However, a risk-based approach that considers risk assessment (E. coli is present in raw milk and causes disease), risk management (boiling of raw milk) and risk communication (educating consumers to boil milk before drinking it) is more appropriate as it is based on evidence of potential harm and not perceptions.

The subject of food safety in informal markets in Africa will be among several topics to be discussed during a side event by the International Livestock Research Institute (ILRI) on the first day of the 6th Africa Agriculture Science Week which takes place on 15-20 July 2013 in Accra, Ghana.

The topic of the ILRI side event is Livestock research for Africa’s food security.

ILRI veterinary epidemiologist and food safety expert Delia Grace will speak on the topic of food safety and aflatoxins.

Aflatoxins are highly toxic metabolites produced by the mould Aspergillus flavus and known to cause suppression of the immune system, liver disease and death in both humans and animals.

Aspergillus can grow in a wide range of foods and feed and thrive under favourable growth conditions of high temperature and moisture content.

In Africa, aflatoxin contamination of cereals, groundnuts and dried fruits leads to an estimated annual loss to food exporters of 670 million US dollars.

Grace leads ILRI’s research program on food safety and zoonoses. She also leads the ‘agriculture-associated diseases’ theme of the CGIAR Research Program on Agriculture for Nutrition and Health, led by the International Food Policy Research Institute (IFPRI).

Grace will address the following questions:

  • What are risk-based approaches to food safety in informal markets where most of the poor buy and sell?
  • How should we deal with food safety dynamics: livestock revolution, urbanization and globalization?
  • How can we better understand the public health impacts of aflatoxins?

Other topics that will be discussed at the side event are

Read more about ILRI’s food safety projects in Africa

For more information about the 6th Africa Agriculture Science Week, follow updates on the blog or the Twitter feed #AASW6.

A new 3-minute video presents an overview of the work that the International Livestock Research Institute (ILRI) is doing towards the prevention and control of agriculture-associated diseases.

This is one of the key themes of the CGIAR Research Program on Agriculture for Nutrition and Health, which is led by the International Food Policy Research Institute (IFPRI).

This CGIAR Research Program was started in 2012 to investigate the links between agriculture, nutrition and health in poor nations.

The program aims at improving the nutritional and health benefits of the farming sector while mitigating the risks posed by diseases that are spread through food and water, as well as those that can be passed from animals to people (zoonotic diseases).

In addition to a focus on agriculture-associated diseases, it also carries out research on food value chains, biofortification, and integrated development policies and programs on agriculture, nutrition and health.

View the video, The prevention and control of agriculture-associated diseases

The prevention and control of agriculture-associated diseases from FILM for SCIENCE in AGRICULTURE on Vimeo.

You are welcome to share this video with research colleagues and partners or embed it in your PowerPoint/Prezi presentations on agriculture, nutrition, health and food safety.

Live chicken vendor

A vendor weighs live chicken for sale in Hung Yen province, Vietnam (photo credit: ILRI/Nguyen Ngoc Huyen).

The first ever short course on One Health and EcoHealth in Vietnam – hosted by the Center for Public Health and Ecosystem Research (CENPHER) at the Hanoi School of Public Health (HSPH) and the International Livestock Research Institute (ILRI) – took place on 27-30 May 2013 in Hanoi.

While Vietnam is a part of the EcoHealth network in the Southeast Asia region, no formal EcoHealth training program existed in the country before the launch of this course.

EcoHealth is an emerging, multi-disciplinary field of study that examines how ecosystem changes affect human health so as to prevent new diseases from emerging.

The participants were an international, multi-disciplinary and multi-sector group drawn from various countries across the globe, including Indonesia, Malaysia, the Netherlands, Singapore, Thailand, the United States of America and Vietnam.

The course, which was run by regionally based trainers, highlighted the conceptual framework of EcoHealth and One Health and its potential usefulness in advancing the agenda of public health. Specifically, activities generated from the workshop provided a chance to demonstrate how risk analysis can be used as a tool in developing strategies to prevent and control infectious diseases.

Through the introduction of concepts and didactic methods, application of case studies and participation in fieldwork, the course participants learned about the theory and major concepts of EcoHealth, and honed the skills necessary to apply the principles of One Health and EcoHealth in their respective fields of expertise.

Following the successful inception of One Health and EcoHealth training in Vietnam, CENPHER now plans to incorporate an EcoHealth course into a comprehensive and innovative public health training program. To do this, CENPHER will collaborate with various EcoHealth initiatives currently working in Southeast Asia, namely,

Beyond the immediate successes of expanding the scope of EcoHealth concepts and applications, the community at HSPH and CENPHER hopes that the output of this workshop will mark the start of continued growth, sustained partnerships and lasting opportunities for collaborative learning.

Poultry seller in a 'wet market' in Indonesia

A women sells live ducklings in a ‘wet market’ in Indonesia (photo credit: ILRI/Christine Jost).

On 29 January 2013, Canada’s International Development Research Centre (IDRC) and the International Livestock Research Institute (ILRI) organized a half-day workshop at the 2013 Prince Mahidol Award Conference entitled Cross-sectoral collaboration for health and sustainability: a new agenda for generating and assessing research impact in the face of complexity.

This pre-conference workshop convened nearly 60 international researchers, practitioners, policymakers and representatives from donor agencies and international organizations to address two contemporary challenges in global health research and practice:

  1. How do we measure and attribute the success and impact of integrated, transdisciplinary and cross-sectoral research and interventions? Further, how do we effectively and coherently communicate these successes to key global health policymakers?
  2. How can we integrate multiple lines of evidence and knowledge in order to achieve gains amongst a family of desired outcomes: the improvement of human and animal health, generation of impact for community members and policymakers, and the promotion of ecological and social sustainability?

The summary report of the workshop is now published, presenting the highlights and reflections which emerged from the workshop and its discussions.

“It is hoped that the key findings will enhance the proficiency of researchers to influence and impact regional and global health policy debates,” the authors say.

“Further, lessons from the workshop may inform priority setting for future research agendas in international One Health, EcoHealth and global health research.”

ILRI’s experiences in using EcoHealth approaches to better manage zoonoses in Southeast Asia took centre stage during a poster session at the 2013 Prince Mahidol Award Conference.

The conference was held in Bangkok, Thailand from 29 January to 2 February 2013.

Smallholder pig production in northern Viet Nam

Farmer Ma Thi Puong feeds her pigs on her farm near the northern town of Meo Vac, Vietnam. Intensification of livestock farming has been found to increase the risk of zoonotic disease transmission (photo credit: ILRI/Stevie Mann).

Modern farming practices, such as intensified livestock production, as well as environmental and biodiversity changes can be linked to the new wave of zoonotic diseases, according to a new study published in the 21 May 2013 edition of the Proceedings of the National Academy of Sciences (PNAS).

Human population growth and the expansion of agriculture to meet the ever-rising demand for food have been identified as the key drivers of recent outbreaks of emerging and re-emerging zoonotic diseases.

These human behavioural changes have led to encroachment of wildlife habitats, resulting in greater interactions between people, livestock and wildlife and increased chances of spillover of potential pathogens from wildlife to livestock and, consequently, people.

“Intensive livestock farming, especially of pigs and poultry, increases the risk of disease transmission due to increased population size and density,” the study reveals.

Environmental changes arising from settlement and agriculture, including land fragmentation, deforestation and replacement of natural vegetation with crops, alter the structure of wildlife population, giving rise to new environmental conditions that favour specific hosts, vectors and pathogens.

The study was carried out in form of a systematic review by a multidisciplinary team of researchers from the International Livestock Research Institute (ILRI) and the Royal Veterinary College, University of London.

The research team sought to analyze qualitatively scientific evidence on the effect of agricultural intensification and environmental change on the risk of zoonoses transmission at the interface of humans, livestock and wildlife.

While the study has identified a clear link between the threat of zoonotic disease and the wildlife-livestock interface, it does not adequately address the complex interactions between the environmental, social and biological drivers of pathogen emergence.

For this reason, there is need to carry out local interdisciplinary studies that can come up with locally relevant solutions to tackle the threat of emerging and re-emerging zoonoses, the authors conclude.

Delia Grace, veterinary epidemiologist and food safety expert at ILRI, is among the co-authors of the study. Grace also leads the agriculture-associated diseases theme of the CGIAR Research Program on Agriculture for Nutrition and Health.

Read the full-text article

Citation: Jones BA, Grace D, Kock R, Alonso S, Rushton J, Said MY, McKeever D, Mutua F, Young J, McDermott J and Pfeiffer DU. 2013. Zoonosis emergence linked to agricultural intensification and environmental change. Proceedings of the National Academy of Sciences of the United States of America (PNAS) 110(21): 8399-8404.

Aflatoxin-contaminated groundnut kernels

Aflatoxin-contaminated groundnut kernels from Mozambique. The Partnership for Aflatoxin Control in Africa has identified five priority strategic areas for action towards control of aflatoxins in Africa (photo credit: IITA).

Regional and international experts in agriculture, health, research and trade have drawn up a plan of action for the control of aflatoxins in Africa, following a strategy development workshop organized by the Partnership for Aflatoxin Control in Africa held on 10-12 April 2013 in Dar es Salaam, Tanzania.

“Control of aflatoxins is needed to achieve greater agricultural development, food security and improve health, particularly in Africa where contamination is widespread and often acute,” said Yemi Akinbamijo, head of the Agriculture and Food Security Division of the African Union Commission.

The workshop participants identified five priority strategic thematic areas for action:

  • Research and technology for control of aflatoxins
  • Legislation, policies and standards in the management of aflatoxin in Africa
  • Growing commerce and trade while protecting lives from aflatoxins
  • Enhancing capacity building on aflatoxin management, control and regulatory processes to ensure reduced exposure
  • Public awareness, advocacy and communication

Aflatoxins are highly toxic metabolites produced by the mould Aspergillus flavus and known to cause suppression of the immune system, liver disease and death in both humans and animals.

Aspergillus can grow in a wide range of foods and feed and thrive under favourable growth conditions of high temperature and moisture content.

The Food and Agriculture Organization (FAO) estimates that 25% of the world’s food crops are affected by aflatoxins, with countries in the tropics and subtropics at most risk.

Aflatoxin contamination can occur before crops are harvested when temperatures are high, during harvest if wet conditions occur and after harvest if there is insect damage to the stored crop or if moisture levels are high during storage and transportation.

In Africa, aflatoxin contamination of cereals, groundnuts and dried fruits leads to an estimated annual loss to food exporters of 670 million US dollars.

Among the over 110 experts who attended the strategy development workshop were three scientists from the International Livestock Research Institute (ILRI) involved in food safety research as part of the agriculture-associated diseases component of the CGIAR Research Program in Agriculture for Nutrition and Health (A4NH).

Benoit Gnonlonfin and Jagger Harvey of the ILRI-Biosciences eastern and central Africa hub are involved in a collaborative project, Capacity and Action for Aflatoxin Reduction in Africa, aimed at establishing a regional mycotoxin analytical platform with state-of-the-art diagnostic technology that will enable better detection and control of aflatoxin contamination in maize in Kenya and Tanzania.

Delia Grace is a veterinary epidemiologist and food safety expert and leads of ILRI’s Food Safety and Zoonoses Program as well as the agriculture-associated diseases component of A4NH.

Grace is involved in the project Measuring and mitigating the risk of mycotoxins for poor milk and maize producers and consumers in Kenya (MyDairy), which aims at improving food safety through reducing the risk of mycotoxins within the feed-dairy chain in Kenya.

The key aspects of the MyDairy project are:

  • integrated risk and economic assessment of the Kenyan feed-dairy chain;
  • investigation of technologies and strategies to reduce mycotoxins risk in the feed-dairy chain; and
  • impact assessment of a package of post-harvest strategies for reducing aflatoxins in maize.

Erastus Kang’ethe, a meat and milk expert at the University of Nairobi, who also attended the workshop, is one of the partners in the MyDairy project.

Access the workshop documents and presentations

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