Zoonotic Diseases


Delia Grace presents on zoonotic diseases, UNEP Nairobi, 20 May 2016
ILRI veterinary epidemiologist Delia Grace presenting at the United Nations Environment Programme (UNEP) Science-Policy Forum that preceded the second session of the United Nations Environment Assembly (UNEA-2), on 20 May 2016 (photo credit: ILRI).

The United Nations Environment Programme (UNEP) held its first global Science-Policy Forum in Nairobi, Kenya on 19-20 May 2016 as part of the overall programme of the second session of the United Nations Environment Assembly (UNEA-2) held on 23-27 May 2016.

The forum offered a platform to the science community to engage with policymakers and civil society stakeholders on the science and knowledge needed to support informed decision-making to deliver on the environmental dimension of the 2030 Agenda for Sustainable Development.

Delia Grace, a veterinary epidemiologist at the International Livestock Research Institute (ILRI), took part in the forum as a panellist for the launch of the UNEP Frontiers 2016 report on emerging issues of environmental concern.

Her presentation on zoonotic and emerging infectious diseases focused on the global burden of zoonotic diseases (diseases that can be transmitted between animals and people), the drivers of disease (among them, land use change, environmental degradation and climate change) and how the multidisciplinary One Health approach can be used to support timely response to the threat of zoonotic diseases.

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Zoonotic diseases are also featured in a chapter in the UNEP Frontiers 2016 report, Zoonoses: Blurred lines of emergent disease and ecosystem health by Delia Grace and ILRI colleagues Bernard Bett, Hu Suk Lee and Susan MacMillan.

The hidden dangers of irrigation in Kenya

By Imogen Mathers

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For farmers in Kenya, creative ways to irrigate crops can be the difference between a harvest failing or thriving. In this drought-prone country, access to reliable water sources is a daily challenge.

Few would argue with the need for better irrigation. Yet certain techniques introduced by the government to spur food production have dangerous side effects, warns Bernard Bett, a veterinary epidemiologist at the International Livestock Research Institute (ILRI) in Kenya.

The pools and canals that underpin flood irrigation create ideal conditions for mosquitoes to thrive, and are a draw for wildlife to gather and drink. This confluence of elements forms a perfect petri dish for zoonotic diseases such as malaria and dengue to circulate between wildlife, livestock, humans and insects.

Instead, Bett suggests exploring alternative techniques such as drip irrigation, a small change that can play a big part in keeping people safe from vector-borne diseases.

The interview was recorded on 18 March 2016 at One Health for the Real World, a symposium in the United Kingdom organised by the Dynamic Drivers of Disease in Africa consortium and the Zoological Society of London.

This article was originally published on SciDev.Net. Read the original article.

ILRI news

MERS-Coronavirus_NIADTransmission electron micrograph of Middle East Respiratory Syndrome coronavirus, MERS-CoV (image credit: NIAID). MERS-CoV belongs to the coronavirus family. Human coronaviruses were first identified in the mid-1960s; MERS-CoV was first reported in 2012 in Saudi Arabia. Coronaviruses can also infect animals. Named for the crown-like spikes on their surface, coronaviruses are common in people, usually causing mild to moderate upper-respiratory tract illnesses. Two exceptions are the MERS-CoV and the SARS (Severe Acute Respiratory Syndrome)-CoV.

A new study published in the science journal Emerging Infectious Diseases reports that two individuals in Kenya have tested positive for the presence of antibodies to Middle East Respiratory Syndrome coronavirus (MERS-CoV). Neither person is ill or recalls having any symptoms associated with MERS.

There is no evidence of a public health threat and scientists concluded that the infections caused little or no clinical signs of illness. But they plan follow-up studies, as this is the…

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AITVM conference logo 2016

The holistic concept of ‘One World-One Health’ in disease prevention and control will be among the topics of discussion at the first joint international conference of the Association of Institutions for Tropical Veterinary Medicine (AITVM) and the Society of Tropical Veterinary Medicine (STVM) which is scheduled to place on 4-8 September 2016 in Berlin, Germany.

AITVM is a foundation of 24 veterinary faculties and livestock institutes based in Africa, Asia and Europe with the mandate to improve human health and quality of life by means of increased and safe food production in tropical regions through enhancement of research, training and education in veterinary medicine and livestock production within the framework of sustainable development.

STVM is made up of scientists, veterinarians and students from more than 40 countries with common interests in tropical veterinary medicine. It is a non-profit organization whose purpose is the advancement of tropical veterinary medicine, hygiene and related disciplines.

The joint conference will bring together animal health and production experts, senior and junior career researchers and students from all over the world to discuss research and development topics including animal and zoonotic disease control, food safety, genetic resources and biodiversity, rural development and animal production, training and capacity building and animal welfare.

The conference is organized by the Institute for Parasitology and Tropical Veterinary Medicine and the Food and Agriculture Organization of the United Nations Reference Centre for Veterinary Public Health of the Freie Universität Berlin.

The co-organizing institutions are:

  • the Friedrich-Loeffler Institute – Federal Research Institute for Animal Health
  • the Federal Institute for Risk Assessment
  • the German Veterinary Medical Society
  • Vétérinaires Sans Frontières Germany
  • the Albrecht Daniel Thaer-Institute of Agricultural and Horticultural Sciences of the Humboldt-Universität zu Berlin

The conference organizers are now accepting abstracts. The deadline for submission of abstracts is 15 March 2016.

Visit the conference website for more information.

Cow in Kenya

Cow in Kenya. A new Rift Valley fever risk map for Kenya will help develop prevention and control measures to combat the disease in the country (photo credit: ILRI/Stevie Mann).

A new Rift Valley fever risk map for Kenya, based on data from a period spanning over 50 years, will be an important tool for use in developing measures to prevent and control the disease in the country.

Rift Valley fever is a viral disease that affects animals such as cattle, sheep, camels and goats. It is also a zoonotic disease, meaning it can be transmitted from animals to people.

Rift Valley fever epidemics occur every 3 to 10 years in specific regions of the Greater Horn of Africa, southern and western Africa and in the Arabian Peninsula, resulting in high rates of infection and death among people and livestock.

In Kenya, the most recent outbreaks of the disease occurred in 1997-98 and 2006-07. Experts agree that the severity of Rift Valley fever epidemics can be reduced through the use of effective early warning systems followed by rapid implementation of prevention and control measures.

In 2008, international experts and decision-makers from eastern Africa developed a risk-based decision support framework designed to guide responses during various stages of the Rift Valley fever disease cycle.

Now, a team of researchers from Kenya, the Netherlands and the United States of America has added to the arsenal of tools to prevent and control Rift Valley fever by using surveillance data from 1951 to 2007 to develop a Rift Valley fever risk map for Kenya.

The map shows the risk of an outbreak of the disease for each of the 391 administrative divisions in the country (based on the 1999 administrative map), classifying the divisions as high, medium or low risk.

The authors of the study say that the Rift Valley fever risk map will provide the Government of Kenya with an evidence-base from which it can respond to a Rift Valley fever epidemic warning as well as develop long-term prevention and control programs in high-risk areas.

The map is published in an article in the journal PLOS ONE (25 Jan 2016): Predictive factors and risk mapping for Rift Valley fever epidemics in Kenya

Citation
Munyua, P.M., Murithi, R.M., Ithondeka, P., Hightower, A., Thumbi, S.M., Anyangu, S.A., Kiplimo, J., Bett, B., Vrieling, A., Breiman, R.F. and Njenga, M.K. 2016. Predictive factors and risk mapping for Rift Valley fever epidemics in Kenya. PLOS ONE 11(1): e0144570.

Catch of the day, Khulna, Bangladesh. Photo by Yousuf Tushar.

Catch of the day, Khulna, Bangladesh. Fish are among the aquatic hosts of microsporidia, a group of emerging foodborne parasites. (photo credit: WorldFish/Yousuf Tushar).

In December 2015, the World Health Organization published a report of the first ever global and regional estimates of the burden of foodborne diseases.

The report estimates the burden of foodborne diseases caused by 31 agents – bacteria, viruses, parasites, toxins and chemicals – and shows that almost 1 in 10 people fall ill every year from eating contaminated food and 420,000 die as a result.

Children under five years of age are at particularly high risk, with 125,000 children dying from foodborne diseases every year. Africa and Southeast Asia have the highest burden of foodborne diseases.

Microsporidia are among the many contributors to the global burden of foodborne disease, although they are not currently considered to be priority foodborne parasites.

Microsporidia are a group of spore-forming parasites that infect a wide range of host organisms, including humans. People can get infected with microsporidia through ingesting contaminated food and water. People with weakened immune systems are at particularly high risk of infection.

To address the growing threat of this emerging group of pathogens, a group of experts met at a symposium entitled “Microsporidia in the animal to human food chain: An international symposium to address chronic epizootic disease”. The meeting was sponsored by the Organisation for Economic Cooperation and Development and held in Vancouver, Canada in August 2015.

Kristina Roesel, a scientist at the International Livestock Research Institute (ILRI), presented a paper entitled “Parasites in food chains”. Her presentation contributed to a collaborative review article, “Microsporidia – Emergent pathogens in the global food chain”, published in the journal Trends in Parasitology (18 Jan 2016).

The article examines the threat of microsporidia in food, water and major food production chains. The authors note that climate change may result in a greater disease burden in hosts from all environments and thus increase the contact rate between infected animals and humans. A One Health approach will, therefore, be useful to manage the risks of microsporidian infections in wildlife, food animals and humans.

Local breed sow and piglets on a farm in Masaka district, Uganda

Local breed sow and piglets on a farm in Masaka district, Uganda (photo credit: ILRI/Eliza Smith).

Zoonotic diseases are most dangerous when they take animal and human health workers by surprise, giving the public and disease control officials no advance warning or time to put prevention measures in place. The recent Ebola outbreak in West Africa illustrates the adverse consequences of trying to tackle a disease outbreak too late and with little information.

Ebola is a serious but mysterious disease; in Uganda, there is little solid information on the reservoir and transmission of Ebola. However, research findings in the last few decades have given rise to speculation that there could be associations between pigs and Ebola.

Currently, there is no evidence that pigs have had any role in past outbreaks of Ebola virus disease. But given the huge importance of pigs to the Ugandan economy, diet and livelihoods, it is important to investigate any potential links sooner rather than later.

A recent study by the International Livestock Research Institute (ILRI) argues there are several factors that support the potential role of pigs in the transmission of Ebola to humans in Uganda. It is critical that this hypothesis be investigated in order to understand the risks to the country’s burgeoning pig production industry.

A spatial representation of potential risk factors for zoonotic transmission involving pigs in Uganda could be used to initiate further investigations into Ebola and other zoonotic diseases known to affect pigs in Uganda.

The researchers call for a One Health approach to the continued research. The benefit of this multidisciplinary approach is that limited resources can be utilized efficiently to improve the health and livelihoods of Ugandans through enhanced food safety and security, and the preservation of important ecosystem services, such as those provided by bats and other wildlife.

Clear and consistent risk communication from all research partners will be of utmost importance in preventing hysteria and delivering good outcomes for wildlife conservation and livelihoods.

Download the policy brief, One Health approach recommended in investigating and communicating the potential role of pigs in transmitting Ebola in Uganda written by Eliza Smith of KYEEMA Foundation and Christine Atherstone and Delia Grace of ILRI.

Orma Boran cattle crossing a river in Kenya

Orma Boran cattle crossing a river in Kenya. Both cattle and people can be infected with Rift Valley fever (photo credit: ILRI /Rosemary Dolan).

Recent climate predictions suggest East Africa may be in line for an epidemic of Rift Valley fever – an infectious disease which can hit people, their livestock and livelihoods, and national economies hard.

Data from the Climate Prediction Center and International Research Institute for Climate and Society suggest there is a 99.9% chance there will be an El Niño occurrence this year, with a 90% chance it will last until March/April 2016.

At least two of the most recent Rift Valley fever epidemics in East Africa—those in 1997-98 and 2006-07—were associated with El Niño weather patterns, with Kenya suffering losses amounting to US$32 million.

Given the strong predictions of an El Niño occurrence, and the established association between El Niño and Rift Valley fever risk, countries in the Horn of Africa need to start preparing to manage the developing risk.

In particular, public education on the linkages between the expected weather patterns and disease risk is vital to minimize human exposure to the disease should an epidemic occur.

Read the full article by Bernard Bett, a veterinary epidemiologist at the International Livestock Research Institute (ILRI).

Maurice Murungi receives award for best oral presentation by students at Safe Pork 2015 conference

Maurice Murungi, a graduate fellow attached to the Urban Zoo project, receives the award for best oral presentation by students at the Safe Pork 2015 conference (photo credit: ILRI/Fred Unger).

With rapidly increasing populations and unprecedented rates of urbanization, the demand for meat also rises. Much of this demand is being met by poultry and pig meat as production is well placed to scale up because of short cycles, large numbers of offspring and ability to grow fast on cereal feeds.

In the case of pork, however, one crucial barrier must be overcome if it is to contribute optimally to feeding the future: pork safety. Indeed, since prehistoric times, pork has been subject to taboos and it has been argued that this is because of the large number of parasites and pathogens that pigs can carry.

The biennial Safe Pork conference is the premier meeting for researchers, industry and policymakers concerned with the safety of pork. This year, the meeting was held on 7-10 September in Porto, a coastal city in Portugal, and was co-organized by Spanish and Portuguese universities.

Scientists from the International Livestock Research Institute (ILRI) presented findings from the Livestock and Fish and Agriculture for Nutrition and Health research programs in the smallholder pig sectors of Uganda and Vietnam as well as from the Urban Zoo project on urban livestock value chains in Kenya and work on possible links between pork production and antimicrobial resistance.

Three ILRI scientists (Delia Grace, Maurice Murungi and Fred Unger) attended as well as visiting scientist Pablo Alarcon. Although our delegation was small, our impact was high and ILRI was awarded two of the four ‘best in show’ prizes: Maurice accepting the prize for best oral presentation by students on behalf of the Urban Zoo team and Delia the prize for best poster on behalf of the PigRisk team.

The conference was an excellent snapshot of the big issues in pork safety. There were several presentations on the most serious zoonotic pathogens in modern pork industries: Salmonella, Campylobacter and Listeria.

Emerging pathogens were of obvious concern with presentations on hepatitis E and livestock-associated Staphylococcus. In his sum up, the chair said that antimicrobial resistance was the issue of the day; this was witnessed by two sessions on this important topic. Both economics and One Health had a profile.

Overall, the focus of the conference was mostly on intensive swine production in Europe and North America. This had the side effect of drawing more attention to ILRI presentations as participants were interested to hear views from the South and in a globalized world, disease is not a regional problem.

As was pointed out, Denmark may successfully reduce treatment regimes from 20 milligrams to 10, but if countries elsewhere are using thousands of tons of antibiotics a year, their achievement will have little impact in curbing rising antimicrobial resistance.

The conference format was all plenaries, increasing the salience of presentations, and industry was well represented from both pharmaceutical and production sectors.

All in all, the conference was a good opportunity to disseminate ILRI research, get updated on pork safety and network for future collaboration. The next Safe Pork meeting will be held in 2017 in Brazil.

Listed below are the ILRI presentations at the Safe Pork 2015 conference.

Assessing and understanding food safety risk practices in Nairobi pork food system: A value chain approach
Murungi, M.K.; M.; Muinde, P.; Akoko, J.; Rushton, J.; Fèvre, E.M.; Dominguez-Salas, P.; Muloi, D.; Häsler, B.; Alarcon, P.

Food safety challenges in smallholder pig value chains in Vietnam: From an assessment to feasible interventions using an integrated approach
Unger, F.; Lapar, L.; Van Hung, P.; Dang-Xuan, S.; Hong Ngan, P.; Rich, K.M.; Nguyen, H.; Grace, D.

Market based approaches for food safety and animal health interventions in smallholder pig systems: The case of Vietnam
Rich, K.M.; Thu Huyen, N.T.; Nam Ha, D.; Duong Nga, N.T.; Xuan, V.K.; Trung, N.X.; Van Long, T.; Van Hung, P.; Unger, F.; Hamza, K.; Lapar, L.

Present and future use of antimicrobials in pigs in developing countries and case studies from Uganda and Vietnam
Grace, D.; Unger, F.; Roesel, K.; Tinega, G.; Ndoboli, D.; Sinh, D.X.; Nguyen-Viet, H.; Robinson, T.

Risk-based approach for food safety applied to pork value chain in Vietnam
Nguyen-Viet, H.; Sinh, D.X.; Hanh, T.T.T.; Unger, F.; Grace, D.; Phuc, P.D.; Makita, K.

Serological and molecular investigation for brucellosis in swine in selected districts of Uganda
Erume, J.; Roesel, K.; Dione, M.M.; Ejobi, F.; Mboowa, G.; Kungu, J.; Akol, J.; Pezo, D.; El-Adawy, H.; Melzer, F.; Elschner, M.; Neubauer, H.; Grace, D.

Blog post contributed by ILRI scientists Delia Grace and Fred Unger

ILRI Asia

The International Livestock Research Institute (ILRI) recently supported and co-organized a symposium on food safety, zoonoses and EcoHealth in Thailand.

ILRI-supported symposium on food safety, zoonoses and Ecohealth ILRI scientists Fred Unger and Hung Nguyen with Pudji Astuti, Vice Dean, Vet Faculty, University of Gadjah Mada (second from left) and other researchers from the region at the Chiang Mai symposium (Photo credit: ILRI/Duong Van Nhiem).

The fourth Food Safety and Zoonoses Symposium for Asia Pacific, which also included the second Regional EcoHealth Symposium, held 3-5 August 2015 in Chiang Mai, brought together experts to share knowledge and information on food safety and zoonoses and to provide a platform for recent EcoHealth research.

This year’s theme was ‘Professional learning community for human–animal–environmental health’.

The symposium focused on several important themes including assessment of biological and chemical risks in food system, antimicrobial resistance in humans and animals, emergence of zoonoses and vector-borne diseases, innovation in surveillance and epidemiological tools…

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